Jurnal Sehat Indonesia (JUSINDO)
type: channel
description: Journal Title Jurnal Sehat Indonesia (JUSINDO) DOI Prefix 10.59141 by Crossref Frequency 2 Issues per year (January & July) ISSN Online 2775-3077 Editor in Chief Cucu Herawati Publisher Publikasi Indonesia Indexing Crossref | Garuda Citation Analysis Google Scholar| Dimensions Jurnal Sehat Indonesia (Jusindo) is a double blind peer-reviewed academic journal and open access to health science fields. The journal is published biannual by CV. Publikasi Indonesia. Jurnal Sehat Indonesia (Jusindo) provides a means for ongoing discussion of relevant issues that fall within the focus and scope of the journal that can be empirically examined. This journal publishes research articles covering approach, which includes: Public Health, Occupational Health and Safety (Occupational Health; Hyperkes), Health Policy (and Health Analyst), Nutrition Science, Epidemiology, Environmental Health Engineering, Health Promotion, Life Insurance and Health Sciences, Environmental Health, Sports Science, Nursing Science, Obstetrics, Hospital Administration, Entomology (Health, Phytopathology), Biomedical Sciences, Ergonomics, Occupational Physiology, Physiotherapy, Medical Analyst, Physiology (Sports), Reproductive (Biology and Health), Acupuncture, Medical Rehabilitation.Journal has become a member of Crossref (Prefix: 10.59141) with Online ISSN 2775-3077 and Print ISSN 2775-0892
publisher: CV. Publikasi Indonesia
language: en-US
publication name: Jurnal Sehat Indonesia (JUSINDO)
issn: 2775-3077
copyright: Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under aCreative Commons Attribution-ShareAlike 4.0 International (CC-BY-SA). that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
items: The Potential of Silver Nanoparticles as Antibacterial and Antibiofilm Agents in Bacteria that Cause Periodontal Disease — A Literature Review
items: Single-Visit Root Canal Treatment on a Mandibular First Premolar with Three Root Canals
items: Repeat Acute Coronary Syndrome Following Percutaneous Coronary Intervention: A Case Report
items: Concurrent Intratonsillar, Peritonsillar, and Retropharyngeal Abscesses: Case Report of Multiple Deep Neck Space Infection
items: Sodium Zirconium Cyclosilicate Compared with Polystyrene Sulfonate for the Management of Hyperkalemia in Chronic Kidney Disease: A Systematic Review
items: Systematic Review Factors that Affect the Occurrence of Stunting
items: Relationship Between Pain Intensity and Workload with The Functional Degree of Low Back Pain in Warehouse Workers at The BULOG Rice Warehouse in Cirebon City
items: The Relationship between the Level of Adherence to Antenatal Care and the Incidence of Chronic Energy Deficiency among Pregnant Women in Areas with a High Prevalence of Intellectual Disabilities
items: The Role and Challenges of E-Medical Records Implementation in Indonesia's Health System: Legal and Technological Perspectives
items: Potential for Blood Glucose Reduction by Indonesian Plant Leaf Extracts: Systematic Review of in Vivo Studies
items: Short-Chain Fatty Acids and Neurodegeneration in Alzheimer's Disease: A Narrative Review
items: Management of Otomycosis in Pregnancy: A Case Study
items: Pengaruh Edukasi Manajemen Nyeri Persalinan Non Farmakologi Terhadap Tingkat Pengetahuan Ibu Hamil Trimester III di TPMB Kusnaenih
items: The Relationship Between Age, Stress Levels, Physical Activity, and Sleep Quality and The Incidence of Hypertension Among The Elderly
items: Transient Gross Hematuria Following Urethral Catheterization in a Patient with Severe Intravesical Prostatic Protrusion: A Case Report from a Resource-Limited Setting
items: Neuroprotective Effects of Antioxidants in Alzheimer's Dementia: A Literature Review
items: Characteristics of Cataract Surgery at the Banten Regional General Hospital in 2024
items: Recurrent Inguinal Hernia in an Elderly Male Patient: A Case Report
items: Differential Expression Analysis Identifies Novel Regulatory Genes in Endometriosis
items: Analysis of Infection-Causing Factors and Antibiotic Sensitivity to the Degree of Ulcers in Diabetes Mellitus Patients
items: Gingivektomi Pada Enlargement Gingiva Karena Malposisi Gigi Individual
items: Models and Effectiveness of Structured Discharge Planning in the Poststroke Care Transition: A Systematic Literature Review
items: Postoperative Bleeding Following Involutional Entropion Surgery in an Elderly Patient with a History of Dual Antiplatelet Therapy Use: A Case Report
items: The Role of Synbiotics in Modulating the Gut–Brain Axis in Attentiondeficit/Hyperactivity Disorder: A Systematic Review
items: A Comprehensive Systematic Review of the Association Between Vitamin D Deficiency and Alopecia Areata
items: Overview of the Level of Knowledge and Behavior of Social Rehabilitation and Child Care Center (BRSPA) Officers in Bimomartani Regarding COVID-19
items: A Lifestyle with Moderate-to-Vigorous Physical Activity Lowers Resting Heart Rate in Adolescents
items: Effectiveness of Balloon Sinuplasty Compared to Functional Endoscopic Sinus Surgery in The Management of Chronic Rhinosinusitis
items: Pendekatan Kedokteran Keluarga Melalui Kunjungan Rumah Pada Pasien Diabetes Melitus Tipe 2 Dan Hipertensi Di Kota Surabaya: Sebuah Laporan Kasus
items: Management of Post-Mastoidectomy Retroauricular Wound Dehiscence Using Advancement Flap: Case Report
items: Modified Coronally Advanced Flap Technique for Managing Orthodontic Related Gingival Recession
items: Predictors of Self-Efficacy in Patients with Chronic Obstructive Pulmonary Disease
items: The Effect of Isometric Forearm Contraction Exercises Added to Elderly Gymnastics on Blood Glucose Levels and Blood Pressure Among Older Adults in Kebumen
items: Comparing the Oncological Risk of Hormonal and Non-Hormonal Contraceptives in Cervical Cancer: A Literature Review
items: The Relationship Between Job Type and the Incidence of Osteoarthritis at the Unaaha Community Health Center
items: Quality and Safety Profile of Chili Sauce in Cirebon City
items: The Role of Vitamin D in Endometrial Receptivity for Successful Implantation
items: https://www.jusindo.publikasiindonesia.id.solusipublish.com/index.php/jsi/article/view/503
items: Asuhan Akupunktur pada Penderita Kecemasan di Rumah Sehat Alam Borneo Sangatta
items: Iron Deficiency n Pregnancy and its Impact on Mother and Fetus: A Systematic Review in Experimental Animal Models
items: Design of a Web-Based Daily Inpatient Census Information System Interface at the Kanjuruhan Regional General Hospital
items: https://www.jusindo.publikasiindonesia.id.solusipublish.com/index.php/jsi/article/view/519
items: Rare Case Report: Guillain–Barré Syndrome As A Neurological Complication In Patients With Dengue Fever
items: Targeting TLR4 Signaling Pathway in Degenerative Diseases: Molecular Docking Study of Bioactive Compounds from Ramie (Boehmeria Nivea) as Anti-Inflammatory and Antioxidant Agents

The Potential of Silver Nanoparticles as Antibacterial and Antibiofilm Agents in Bacteria that Cause Periodontal Disease — A Literature Review
type: item
description: Background: Periodontal disease is a chronic inflammatory disease that is closely related to the activity of biofilm-forming pathogenic bacteria, such as Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. Conventional therapies using antibiotics often face limitations in the form of bacterial resistance and side effects. Silver nanoparticles (AgNPs) are reported to have effective antibacterial and antibiofilm activity against a wide range of pathogenic microorganisms. Objective: This literature review aims to examine the potential of silver nanoparticles as antibacterial agents and antibiotics against bacteria that cause periodontal disease. Methods: Literature search was conducted through PubMed, Scopus, and Google Scholar scientific databases with relevant keywords. Results: The results of the study showed that AgNPs are able to inhibit the growth of periodontal bacteria through cell membrane damage, increased membrane permeability, disruption of intracellular metabolic processes, and inhibition of biofilm formation and maturation. Based on these findings, silver nanoparticles have the potential to be developed as an alternative or adjuvant therapy in the control of periodontal infections. Conclusion: However, further research is needed regarding safety and its clinical application.
creator: Fania Alfadin Uba
creator: Komariah Komariah
creator: Ciptadhi Tri Oka Binartha
rights: Copyright (c) 2026 Fania Alfadin Uba, Komariah Komariah, Ciptadhi Tri Oka Binartha https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-04-01
publication date: 2026-04-01
volume: 8
number: 1
starting page: 244
ending page: 253
doi: 10.59141/-.v8i1.495

Single-Visit Root Canal Treatment on a Mandibular First Premolar with Three Root Canals
type: item
description: Background: In root canal treatment, accurate diagnosis of root canal morphology is crucial for treatment success. Vertucci reported that in mandibular premolars, 74% have one canal, 25.5% have two canals, and 0.5% have three canals. Therefore, pre-treatment radiography, careful examination, and appropriate techniques are essential to identify root canal orifices, especially in cases with canal variations. The purpose of this case report is to demonstrate the importance of knowledge about the morphology of the root canal system and how to manage root canal care in the first premolar tooth of the lower jaw with three root canals. Case: A 57-year-old female patient with a complaint of a large cavity of the left lower jaw premolar tooth, no pain and wants to be treated. The radiographic results showed that the tooth pulp was open and the morphology of the root canal showed that there were three root canals. Management: Access opening and search of three root canals is carried out using ultrasonic tips and magnification assistance with a dental microscope. The root canal is prepared with rotary NiTi fileby irrigation using 5.25% sodium hypochlorite, 17% EDTA. Obturation using thermal fill and the use of dental crowns as final restoration will be done at the next visit. Conclusion: An understanding of the morphology of the root canal system and the proper use of tools and materials will influence success in the treatment of complex root canals in premolar teeth with three root canals.
creator: Achmad Junaidi
creator: Annisa Fitria Sari
rights: Copyright (c) 2026 Achmad Junaidi, Annisa Fitria Sari https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-31
publication date: 2026-03-31
volume: 8
number: 1
starting page: 267
ending page: 274
doi: 10.59141/-.v8i1.500

Repeat Acute Coronary Syndrome Following Percutaneous Coronary Intervention: A Case Report
type: item
description: Percutaneous coronary intervention (PCI) is the primary reperfusion strategy for ST-elevation myocardial infarction (STEMI). Despite high procedural success rates, patients remain at risk for recurrent acute coronary syndrome (ACS), particularly those with significant comorbidities. We report a case of recurrent ACS in a patient less than one year following successful primary PCI. A 50-year-old female presented to the emergency department with typical angina, shortness of breath, nausea, and diaphoresis. Her medical history was significant for hypertension, type 2 diabetes mellitus, and a STEMI treated with primary PCI five months prior. Despite reported adherence to dual antiplatelet therapy (DAPT), she presented with tachycardia (104 bpm) and hypotension (155/55 mmHg). Electrocardiography revealed sinus tachycardia with pathological Q waves in leads V1–V4, consistent with a prior anterior myocardial infarction. Laboratory evaluation demonstrated hyperglycemia (228 mg/dL) and elevated cardiac troponin (44.2 ng/mL). The patient was diagnosed with recurrent ACS superimposed on an old anterior myocardial infarction. She was stabilized with loading doses of aspirin and clopidogrel and admitted to the Intensive Cardiac Care Unit (ICCU) for guideline-directed medical therapy, including beta-blockers and high-intensity statins. She was discharged in stable condition after five days. This case illustrates that recurrent ACS can occur shortly after successful revascularization, specifically in patients with persistent cardiovascular risk factors such as uncontrolled hyperglycemia and hypertension. It highlights the critical importance of aggressive secondary prevention, strict glycemic control, and close follow-up to mitigate the risk of adverse cardiac events in the post-PCI period.
creator: Alief Rezkinanda
creator: Sjaiful Anwar
rights: Copyright (c) 2026 Alief Rezkinanda, Sjaiful Anwar https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-01-15
publication date: 2026-01-15
volume: 8
number: 1
starting page: 28
ending page: 34

Concurrent Intratonsillar, Peritonsillar, and Retropharyngeal Abscesses: Case Report of Multiple Deep Neck Space Infection
type: item
description: Deep neck space infections are potentially life-threatening conditions due to their proximity to vital structures such as the airway, major blood vessels, and cranial nerves. These infections may spread rapidly and lead to severe complications, including airway obstruction and sepsis. This study aims to describe a rare case of concurrent intratonsillar, peritonsillar, and retropharyngeal abscesses, as well as to evaluate the effectiveness of conservative management using intravenous antibiotics. This research employed a descriptive qualitative case report approach involving a 32-year-old male patient presenting with progressive throat pain, dysphagia, neck swelling, and a muffled voice. Data were collected through clinical examination, laboratory tests, and radiological imaging, followed by continuous observation during hospitalization. The findings revealed elevated leukocyte levels and radiographic evidence of retropharyngeal space widening. The patient was treated with intravenous cefotaxime and metronidazole, along with supportive therapy. Significant clinical improvement was observed within 48 hours, with resolution of symptoms by the fifth day without surgical intervention. In conclusion, early diagnosis and prompt antibiotic therapy can effectively manage selected cases of multiple deep neck abscesses. Conservative treatment may be considered in stable patients, potentially avoiding invasive procedures while ensuring favorable clinical outcomes
creator: Yovita Hamdani
creator: Henny Widyastuti
rights: Copyright (c) 2026 Yovita Hamdani, Henny Widyastuti https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-04-22
publication date: 2026-04-22
volume: 8
number: 1
starting page: 294
ending page: 306
doi: 10.59141/-.v8i1.506

Sodium Zirconium Cyclosilicate Compared with Polystyrene Sulfonate for the Management of Hyperkalemia in Chronic Kidney Disease: A Systematic Review
type: item
description: Background: Hyperkalemia is a common and potentially life-threatening complication in patients with chronic kidney disease (CKD). Methods: This systematic review followed the PRISMA 2020 guidelines. A comprehensive literature search was conducted using PubMed, ScienceDirect, and the Cochrane Library to identify randomized controlled trials and comparative observational studies involving adult patients with CKD and hyperkalemia. Studies comparing sodium zirconium cyclosilicate (SZC) with polystyrene sulfonate–based binders and reporting efficacy or safety outcomes were included. Data extraction and risk of bias assessment were performed, and a qualitative synthesis of results was conducted due to study heterogeneity. Results: Eight studies were included in the qualitative analysis, comprising seven interventional and hospital-based observational studies involving 690 patients and one large nationwide cohort including more than 70,000 patients. In acute settings, SZC achieved rapid reductions in serum potassium, with greater or comparable efficacy to polystyrene sulfonate–based binders. In chronic management, SZC was associated with earlier normalization and more sustained potassium control. Safety outcomes were generally comparable, with favorable tolerability and patient preference observed for SZC. Discussion: The included studies consistently demonstrated effective potassium lowering with SZC across acute and chronic settings. While heterogeneity and the predominance of observational data limit causal inference, the overall findings support the clinical utility of SZC, particularly in facilitating long-term potassium control and treatment adherence. Conclusion: SZC represents an effective and well-tolerated alternative to polystyrene sulfonate–based binders for the management of hyperkalemia in patients with CKD. Further well-designed randomized studies are warranted to confirm long-term clinical benefits.
creator: Bella Yanita
creator: Januar Ishak Hutasoit
rights: Copyright (c) 2026 Bella Yanita, Januar Ishak Hutasoit https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-02-20
publication date: 2026-02-20
volume: 8
number: 1
starting page: 57
ending page: 68
doi: 10.59141/-.v8i2.463

Systematic Review Factors that Affect the Occurrence of Stunting
type: item
description: Stunting in children aged 24 to 59 months is a health issue related to parenting patterns, social conditions, and family habits in meeting children's needs. This research aims to describe the factors related to the occurrence of stunting based on a review of six field research articles published between 2020 and 2025. Systematic review was conducted by searching articles in PubMed, Google Scholar, and Science Direct databases using keywords "stunting", "factors", "children 24 to 59 months", “health”, and "economy" with inclusion criteria: journal articles from the last 5 years, full text, English/Indonesian language. The results found 6 articles that meet the criteria. The results show that the occurrence of stunting in children aged 24 to 59 months is related to the dynamics of family life, starting from parenting patterns, feeding habits, social conditions, to the household economic situation. The dynamics of family life, starting from parenting patterns, feeding habits, social conditions, to the household economic situation affects the occurrence of stunting in children aged 24 to 59 months.
creator: Rahmah Pujianti
creator: Ummi Kalsum
creator: Dwi Noerjoedianto
rights: Copyright (c) 2026 Rahmah Pujianti, Ummi Kalsum, Dwi Noerjoedianto https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-05-12
publication date: 2026-05-12
volume: 8
number: 1
starting page: 351
ending page: 357
doi: 10.59141/-.v8i1.515

Relationship Between Pain Intensity and Workload with The Functional Degree of Low Back Pain in Warehouse Workers at The BULOG Rice Warehouse in Cirebon City
type: item
description: Low Back Pain (LBP) is a leading cause of global disability and often occurs among informal sector workers who are exposed to high physical loads, such as pelvic coolies. Pain intensity and workload are thought to play a role in the decline in functional capacity, but evidence concerning informal worker populations remains limited. This study aims to analyze the relationship between pain intensity and workload with the functional degree of LBP in pelvic coolies at the BULOG Rice Warehouse in Cirebon City. An analytical observational study with a cross-sectional design was conducted on 38 pelvic coolies who met the inclusion criteria. Pain intensity was measured using the Numeric Rating Scale (NRS), workload was categorized by force weight (<20 kg; 20–30 kg; >30 kg), and functional degree was measured using the Back Pain Functional Scale (BPFS). Bivariate analysis used the Spearman correlation test with a significance level of p<0.05. Most respondents experienced mild pain (52.63%) and a moderate workload (47.4%). The median functional degree of LBP was 55% ± 4.77%. There was a significant relationship between pain intensity and the functional degree of LBP (p=0.001; r=0.530) with moderate correlation strength and a positive direction. No association was found between workload and the functional degree of LBP (p=0.327; r=0.163). Pain intensity was significantly related to the functional degree of LBP in pelvic coolies, whereas workload did not show a meaningful relationship. The management of LBP in informal sector workers needs to focus on pain management and functional capacity improvement through rehabilitative approaches and work ergonomics.
creator: Moh. Irwan Dharmansyah
creator: Maryano Maryano
creator: Kati Sriwiyati
rights: Copyright (c) 2026 Moh. Irwan Dharmansyah, Maryano Maryano, Kati Sriwiyati https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-02-24
publication date: 2026-02-24
volume: 8
number: 1
starting page: 92
ending page: 98
doi: 10.59141/-.v8i2.476

The Relationship between the Level of Adherence to Antenatal Care and the Incidence of Chronic Energy Deficiency among Pregnant Women in Areas with a High Prevalence of Intellectual Disabilities
type: item
description: Chronic energy deficiency among pregnant women remains an important maternal nutrition problem because it may increase the risk of adverse pregnancy outcomes and reflects inadequate nutritional status during pregnancy. Antenatal care adherence is expected to support early detection and prevention of nutritional disorders through routine maternal assessment, nutritional counseling, and anthropometric monitoring. This study aimed to analyze the relationship between antenatal care adherence and the incidence of chronic energy deficiency among pregnant women in Karangpatihan Village, Balong District, Ponorogo Regency, an area known for a high prevalence of intellectual disability. This study used an analytic observational design with a cross-sectional approach. The study population consisted of pregnant women who met the inclusion criteria and had complete data on antenatal care visits and mid-upper arm circumference measurement. Antenatal care adherence was categorized as adherent when respondents completed at least six visits and non-adherent when fewer than six visits were recorded. Chronic energy deficiency was defined as mid-upper arm circumference below 23.5 cm. Data were analyzed using the Chi-Square test. Among 70 respondents, 42 respondents (60%) were non-adherent to antenatal care and 39 respondents (55.7%) experienced chronic energy deficiency. Bivariate analysis showed a significant relationship between antenatal care adherence and chronic energy deficiency (p = 0.001; OR = 0.189; 95% CI: 0.067–0.535). These findings indicate that antenatal care adherence may have a protective role against chronic energy deficiency among pregnant women.
creator: Aniek Luftyannisa
creator: Arief Prijatna
rights: Copyright (c) 2026 Aniek Luftyannisa, Arief Prijatna https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-05-29
publication date: 2026-05-29
volume: 8
number: 1
starting page: 387
ending page: 397
doi: 10.59141/-.v8i1.529

The Role and Challenges of E-Medical Records Implementation in Indonesia's Health System: Legal and Technological Perspectives
type: item
description: The digital literacy gap among medical personnel is a challenge, and the lack of understanding and skills in using information technology may hinder the effective utilization of e-medical records. The purpose of this study is to analyze the impact of e-medical records on the efficiency of health services, as well as evaluate the legal aspects governing their use in Indonesia. This research method uses normative juridical and empirical juridical research approaches; the research subjects consist of medical personnel, hospital managers, and IT system developers. In this research, the legal material collection technique that will be used is the literature collection technique. Overall, although e-medical records present challenges related to data security and privacy that must be addressed seriously, the development of a more comprehensive and clear legal framework will be essential to support the growth of this system as well as protect the rights of patients in the digital era; further regulatory development is still needed to optimize the benefits and overcome the challenges. There is a need for strategic planning that includes a thorough needs assessment, a realistic timeline, and adequate budget allocation; ongoing training for staff; establishment of an internal technical support team and mentoring program for users; and evaluation and monitoring with regular KPI measurement.
creator: Novita Badiningsih
rights: Copyright (c) 2026 Novita Badiningsih https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-10
publication date: 2026-03-10
volume: 8
number: 1
starting page: 150
ending page: 157
doi: 10.59141/-.v8i1.484

Potential for Blood Glucose Reduction by Indonesian Plant Leaf Extracts: Systematic Review of in Vivo Studies
type: item
description: Introduction: Diabetes mellitus is a chronic disease characterized by persistent hyperglycemia. The rising prevalence of diabetes has increased interest in alternative therapies, including herbal medicines. Indonesia has abundant medicinal plants whose leaf extracts contain bioactive compounds with potential antidiabetic effects, yet scientific evidence regarding their effectiveness remains fragmented. Purpose: Therefore, this study aims to systematically review the potential of Indonesian plant leaf extracts in reducing blood glucose levels based on in vivo experimental studies. Method: A systematic review was conducted by following the PRISMA guidelines through a literature search on the Google Scholar and Science Direct databases. The articles analyzed were original studies published between 2020 and 2025 that focused on in vivo studies examining the potential of various leaf extracts to reduce blood glucose levels. Discussion: Phytochemical analysis indicates that leaf extracts may act effectively by providing antioxidant protection to pancreatic beta cells, increasing GLUT4 expression, and inhibiting digestive enzymes. Although their effects can rival standard drugs with a lower risk of hypoglycemia, the current literature still has limitations, particularly the short duration of in vivo testing and the lack of chronic toxicity data. Conclusion: Indonesian plant leaf extracts show promising potential as natural antihyperglycemic agents; nevertheless, further studies involving long-term toxicity evaluation, standardized extraction methods, and clinical trials are required to confirm their safety and effectiveness in humans.
creator: Made Devina Febryanti
creator: I Putu Adi Wibowo
creator: I Made Lingga Tresnadinata
creator: Ni Putu Cempaka Pradnyadewi
creator: Made Ayu Rahayu Agastyane Rahmadewi
rights: Copyright (c) 2026 Made Devina Febryanti, I Putu Adi Wibowo, I Made Lingga Tresnadinata, Ni Putu Cempaka Pradnyadewi, Made Ayu Rahayu Agastyane Rahmadewi https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-18
publication date: 2026-03-18
volume: 8
number: 1
starting page: 223
ending page: 234
doi: 10.59141/-.v8i1.491

Short-Chain Fatty Acids and Neurodegeneration in Alzheimer's Disease: A Narrative Review
type: item
description: Background: Alzheimer Disease remains the most prevalent cause of dementia worldwide, representing a major and escalating global health challenge. Objective: This study aims to examine the role of short chain fatty acids in the pathogenesis and progression of Alzheimer Disease within the framework of the microbiota gut brain axis. Methods: The research employed a qualitative design with a descriptive approach through a narrative literature study. Data were collected through systematic searches of peer reviewed scientific articles published between 2015 and 2026, focusing on gut microbiota dysbiosis, short chain fatty acids, neuroinflammation, amyloid pathology, and cognitive decline in Alzheimer Disease. Document analysis was conducted using thematic identification, data reduction, conceptual categorization, and inductive interpretation to generate a comprehensive synthesis of the evidence. Results: The findings indicate that Alzheimer Disease is consistently associated with reduced abundance of short chain fatty acid producing bacteria and altered circulating and fecal short chain fatty acid profiles, which are linked to impaired blood brain barrier integrity, microglial activation, increased neuroinflammation, amyloid beta accumulation, and tau pathology. Mechanistic insights demonstrate that short chain fatty acids regulate inflammatory signaling pathways, epigenetic modulation, mitochondrial bioenergetics, and metabolic homeostasis. Conclusion: In conclusion, short chain fatty acids function as key metabolic mediators in Alzheimer Disease and represent promising targets for preventive and therapeutic strategies, contributing to a systems biology perspective and supporting microbiome based precision approaches in cognitive health management.
creator: Komang Trisna Sumadewi
creator: Dewa Ayu Agung Alit Suka Astini
creator: Luh Gde Evayanti
creator: Ida Ayu Laxmi Ananda Dewi Manuaba
creator: Ni Made Gita Kusuma Dewi
rights: Copyright (c) 2026 Komang Trisna Sumadewi, Dewa Ayu Agung Alit Suka Astini, Luh Gde Evayanti, Ida Ayu Laxmi Ananda Dewi Manuaba, Ni Made Gita Kusuma Dewi https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-30
publication date: 2026-03-30
volume: 8
number: 1
starting page: 254
ending page: 266
doi: 10.59141/-.v8i1.498

Management of Otomycosis in Pregnancy: A Case Study
type: item
description: Otomycosis is a fungal infection of the external auditory canal that commonly occurs in tropical and humid regions such as Indonesia. Pregnancy is a unique physiological condition characterized by hormonal and immunological changes that may increase susceptibility to fungal infections while simultaneously limiting therapeutic options due to concerns regarding fetal safety. This report details the clinical management of a 25-year-old pregnant patient (G1P0A0) at 24 weeks gestation who presented with complaints of severe pruritus and aural fullness in the right ear. Clinical examination revealed characteristic fungal debris with a "white fluffy" appearance. Management included aural toilet followed by the topical solution, a treatment selected for its high efficacy and established safety during pregnancy. The successful resolution of the infection without maternal or fetal complications reinforces the efficacy of combined mechanical debridement and topical therapy. This case underscores the importance of specialized ENT care in secondary referral hospitals for managing infections in high-risk populations.
creator: Fierda Ovita Azhari
creator: Gustav Syukrinto
rights: Copyright (c) 2026 Fierda Ovita Azhari, Gustav Syukrinto https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-04-14
publication date: 2026-04-14
volume: 8
number: 1
starting page: 275
ending page: 281
doi: 10.59141/-.v8i1.504

Pengaruh Edukasi Manajemen Nyeri Persalinan Non Farmakologi Terhadap Tingkat Pengetahuan Ibu Hamil Trimester III di TPMB Kusnaenih
type: item
description: Labor pain is a natural physiological response caused by uterine muscle contractions during the first stage of labor. In Indonesia, 22% of women experience severe pain and 15% experience pain-related complications, yet 63% of them have never received education on labor pain management. Lack of education leads to mothers being less mentally prepared, leading to anxiety, stress, decreased self-confidence, and difficulty controlling emotions. This study aims to determine the effect of non-pharmacological labor pain management education on the knowledge level of pregnant women in the third trimester at the TPMB (Private Midwifery Practice) Kusnaenih. This study employed a quantitative method with a pre-experimental design approach. The sampling technique performed was a non-probability sampling technique with a total sampling rate of 46 respondents. Primary data were collected, and the Wilcoxon paired t-test was applied for data processing. The Wilcoxon paired t-test showed a significant difference between the pre-test and post- test group averages before treatment, with a p-value of 0.000 <0.005. The video-based education presented information clearly and systematically, making it easier for pregnant women to understand the material, which resulted in an increase in their knowledge level after the intervention. There is an effect of non-pharmacological labor pain management education on the knowledge level of pregnant women in the third trimester at TPMB Kusnaenih. TPMB Kusnaenih is recommended to hold classes for pregnant women as part of antenatal care, using the educational video from this study as one of the educational media.
creator: Nurul Hasna
creator: Anjarwati Anjarwati
creator: Sri Ratna Ningsih
rights: Copyright (c) 2026 Nurul Hasna, Anjarwati Anjarwati, Sri Ratna Ningsih https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-01-23
publication date: 2026-01-23
volume: 8
number: 1
starting page: 44
ending page: 56
doi: 10.59141/-.v8i1.448

The Relationship Between Age, Stress Levels, Physical Activity, and Sleep Quality and The Incidence of Hypertension Among The Elderly
type: item
description: Hypertension is a condition of elevated blood pressure >140/90 mmHg, which is influenced by various factors. One non-modifiable factor is age, as increasing age leads to a decrease in blood vessel elasticity, which increases the risk of hypertension. Furthermore, modifiable factors such as low physical activity, stress levels, and poor sleep quality also play a role in increasing blood pressure. To determine the relationship between age, stress levels, physical activity, and sleep quality with the incidence of hypertension. This study is an observational study with a total sampling technique and uses the Spearman rank test. The sample in this study were elderly people at the Aisyiyah Pajangan Branch with a population of 120 elderly people and 71 elderly people suffered from hypertension. The variables in this study were age, stress level, physical activity and sleep quality as independent variables and hypertension as dependent. The measuring instruments used were the Perceived Stress Scale (PSS-10) for stress levels, the Physical Activity Scale for Elderly (PASE) for physical activity, the Pittsburgh Sleep Quality Index (PSQI) for sleep quality and a sphygmomanometer to measure blood pressure. There is no relationship between age and hypertension p=0.463 (p>0.05), there is no relationship between stress levels and hypertension p=0.324 (p>0.05), there is a relationship between physical activity and hypertension p=0.023 (p<0.05), and there is no relationship between sleep quality and hypertension p=0.413 (p>0.05). There is no relationship between age, stress level, sleep quality and the incidence of hypertension and there is a relationship between physical activity and the incidence of hypertension.
creator: Latifah Oktafianti
creator: Veni Fatmawati
creator: Riska Risty Wardhani
rights: Copyright (c) 2026 Latifah Oktafianti, Veni Fatmawati, Riska Risty Wardhani https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-04-06
publication date: 2026-04-06
volume: 8
number: 1
starting page: 398
ending page: 413
doi: 10.59141/-.v8i1.513

Transient Gross Hematuria Following Urethral Catheterization in a Patient with Severe Intravesical Prostatic Protrusion: A Case Report from a Resource-Limited Setting
type: item
description: Background: Gross hematuria in elderly men frequently raises suspicion of urological malignancy. However, benign anatomical conditions such as severe intravesical prostatic protrusion (IPP) may predispose patients to procedure-related bleeding, particularly following urethral catheterization. Objective: To describe transient gross hematuria following urethral catheterization in a patient with severe intravesical prostatic protrusion and to emphasize the importance of chronological clinical assessment in differentiating benign procedure-related bleeding from possible malignancy. Methods: This study is a descriptive single-patient case report. An 85-year-old man presented with acute urinary retention complicated by septic shock and acute kidney injury. Gross hematuria occurred immediately after urethral catheterization. Clinical evaluation included laboratory investigations and transabdominal ultrasonography. Results: Ultrasonography revealed severe benign prostatic enlargement (estimated volume 176 mL) with grade 3 IPP measuring 2.04 cm. The hematuria resolved spontaneously within 24 hours without clot formation or recurrence. No intravesical mass or hydronephrosis was identified. Conclusion: Severe IPP may predispose elderly patients to transient catheter-induced hematuria due to anatomical distortion and increased mucosal vulnerability. Recognition of this self-limiting presentation is particularly important in resource-limited settings to avoid unnecessary invasive investigations while maintaining appropriate oncologic vigilance.
creator: Muhammad Fadli
creator: Welly Patanasalu
rights: Copyright (c) 2026 Muhammad Fadli, Welly Patanasalu https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-02-27
publication date: 2026-02-27
volume: 8
number: 1
starting page: 108
ending page: 116
doi: 10.59141/-.v8i2.473

Neuroprotective Effects of Antioxidants in Alzheimer's Dementia: A Literature Review
type: item
description: This research aims to analyze the neuroprotective effects of antioxidants in Alzheimer’s disease (AD) by examining their roles in mitigating oxidative stress and related pathological mechanisms. The research employs a qualitative design with a descriptive approach through a literature review, utilizing secondary data from peer-reviewed scientific articles and relevant academic sources. Data were collected through systematic literature searching and analyzed using thematic qualitative methods, including data reduction, categorization, and inductive interpretation. The findings indicate that oxidative stress plays a central role in AD pathogenesis by interacting with amyloid-beta accumulation, tau hyperphosphorylation, mitochondrial dysfunction, neuroinflammation, and metabolic dysregulation. Antioxidants, particularly mitochondria-targeted compounds and natural bioactive substances such as polyphenols and flavonoids, demonstrate significant neuroprotective potential through multi-target mechanisms. However, their clinical effectiveness is limited by factors such as low bioavailability and restricted blood–brain barrier penetration. These findings highlight the importance of developing multi-target therapeutic strategies and advanced drug delivery systems to enhance treatment efficacy. In conclusion, this study contributes to a deeper understanding of the role of antioxidants in AD and supports the shift toward integrative and system-based approaches in neurodegenerative disease management.
creator: Komang Trisna Sumadewi
creator: Saktivi Harkitasari
creator: Ni Putu Diah Witari
creator: Fransiscus Fiano Anthony
rights: Copyright (c) 2026 Komang Trisna Sumadewi, Saktivi Harkitasari, Ni Putu Diah Witari, Fransiscus Fiano Anthony https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-06-12
publication date: 2026-06-12
volume: 8
number: 1
starting page: 438
ending page: 449
doi: 10.59141/-.v8i1.521

Characteristics of Cataract Surgery at the Banten Regional General Hospital in 2024
type: item
description: Cataract is the leading cause of treatable blindness worldwide. Cataract surgery has undergone significant evolution in recent decades, with phacoemulsification becoming the technique of choice in developing countries. This study aims to analyze the characteristics of cataract surgery techniques performed at Banten Regional General Hospital in 2024. This study used a descriptive research design with a cross-sectional approach. Data were obtained from medical records of patients who underwent cataract surgery at Banten Regional General Hospital from January to December 2024. Inclusion criteria included all patients who underwent cataract surgery at Banten Regional General Hospital in 2024. Exclusion criteria included incomplete medical records. Based on the research, a total of 631 cataract surgery cases were found in 2024. The distribution of surgical techniques showed phacoemulsification with intraocular lens (IOL) implantation as the dominant technique, with 625 cases (99.0%), followed by extracapsular cataract extraction (ECCE) with 3 cases (0.5%), and other procedures each with 1 case (0.2%). Monthly distribution showed the highest peak in August (96 cases, 15.2%) and the lowest in December (19 cases, 3.0%). In conclusion, phacoemulsification with IOL is the most dominant cataract surgery technique at Banten Regional General Hospital in 2024, demonstrating the adoption of modern technology in ophthalmology services at regional hospitals.
creator: Java Indra Maulana S
creator: Syifa Husna Mahmudah
rights: Copyright (c) 2026 Java Indra Maulana S, Syifa Husna Mahmudah https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-10
publication date: 2026-03-10
volume: 8
number: 1
starting page: 158
ending page: 166
doi: 10.59141/-.v8i1.481

Recurrent Inguinal Hernia in an Elderly Male Patient: A Case Report
type: item
description: Inguinal hernia is a medical condition characterized by the protrusion of intra-abdominal organs through a weakness in the abdominal wall in the inguinal region. This condition is more common in men and can lead to serious complications such as incarceration and strangulation if not treated properly. The purpose of this study is to describe the clinical characteristics, risk factors, diagnosis, and management of recurrent inguinal hernia through case reports. The method used was a case study of a 60-year-old male patient presenting with severe pain in the lower right abdomen that radiated to the right scrotum. A physical examination revealed the presence of an irreducible right scrotal herniation. The patient had a history of previous bilateral hernioplasty and risk factors including heavy lifting activities. The diagnosis was established based on anamnesis and physical examination, followed by a herniotomy with mesh insertion. The results indicated that increased intra-abdominal pressure and tissue weakness contributed to the recurrence. In conclusion, recurrent inguinal hernia can occur due to persistent risk factors, and surgical treatment with mesh insertion is an effective definitive therapy to prevent further complications.
creator: Ilmida Husniana
rights: Copyright (c) 2026 Ilmida Husniana https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-14
publication date: 2026-03-14
volume: 8
number: 1
starting page: 178
ending page: 187
doi: 10.59141/-.v8i1.489

Differential Expression Analysis Identifies Novel Regulatory Genes in Endometriosis
type: item
description: Background: Endometriosis is a chronic estrogen-dependent inflammatory disorder associated with pelvic pain and infertility. Despite its high prevalence, the molecular regulatory mechanisms underlying disease progression remain incompletely understood. Objective: This study aimed to identify differentially expressed genes (DEGs) and prioritize key regulatory candidates involved in endometriosis pathogenesis using integrative bioinformatics analysis. Methods: Publicly available human transcriptomic datasets comparing endometriotic lesions and normal endometrial tissues were analyzed. Data were normalized and subjected to differential expression analysis using adjusted p-value < 0.05 and |log2 fold change| ≥ 1 as thresholds. Functional enrichment analysis and protein–protein interaction (PPI) network construction were performed to identify enriched pathways and hub genes. Results: A total of 326 significant DEGs were identified, including 189 upregulated and 137 downregulated genes. Enrichment analysis revealed predominant involvement of inflammatory signaling, angiogenesis, extracellular matrix remodeling, and steroid hormone response pathways. Network analysis identified IL6, STAT3, VEGFA, and MMP9 as central upregulated hub genes, while PGR and HOXA10 were among the key downregulated regulators associated with progesterone resistance. Conclusion: Endometriosis exhibits coordinated activation of inflammatory–angiogenic networks and suppression of steroid signaling pathways. The identified hub genes represent potential biomarkers and therapeutic targets, warranting further experimental validation.
creator: Ian Pranandi
rights: Copyright (c) 2026 Ian Pranandi https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-31
publication date: 2026-03-31
volume: 8
number: 1
starting page: 267
ending page: 275

Analysis of Infection-Causing Factors and Antibiotic Sensitivity to the Degree of Ulcers in Diabetes Mellitus Patients
type: item
description: The diabetic foot ulcer prevalence was 6.3% globally and 7.3% in Indonesia. This study analyzes the relationships between the type of germs and antimicrobial susceptibilities to the Wagner’s degree of diabetic-foot-ulcers on patients with type-2 diabetes mellitus admitted to Dr. Moewardi regional hospital. The method used in this observational analysis is a cross-sectional approach. The variables used were the type-of-germs, antimicrobial susceptibilities, and the degree of diabetic-foot-ulcers with the data extracted from 149 inpatients between the period of 2021-2022 and tested with Fisher’s-exact and multinomial-logistic-regressions. Data for the 4-most-frequent germs on the diabetic-foot-ulcers are Pseudomonas aeruginosa (17.4%; 26/149), Escherichia coli (12.8%; 19/149), Klebsiella pneumoniae ss. Pneumoniae (11.4%, 17/149) and Proteus mirabilis (10.7%; 16/149). Data for the 4-most-frequent antimicrobial susceptibilities are ampicillin (20,8%; 31/149), sulfamethoxazole (20,8%; 31/149), gentamicin (18,8%; 28/149) and amikacin (16,1%; 24/149). Data for the 3-most-frequent degree of diabetic-foot-ulcers are the 4th (39.6%; 59/149), 3rd (31.5%; 47/149) and 2nd (19.5%; 29/149) degrees. There is no relationship between the type-of-germs and the degree of diabetic-foot-ulcers (p=0.111). There is a relationship between antimicrobial susceptibilities and the degree of diabetic-foot-ulcers (p=0.009). There is a relationship between the type-of-germs and antimicrobial susceptibilities (p=0,0001). There is a simultaneous relationship between the type-of-germs (p=0.029) and antimicrobial susceptibilities (p=0.032) to the degree of diabetic-foot-ulcers (p=0.005). Therefore, it is necessary to conduct microbial culture and antimicrobial susceptibility tests on all patients with diabetic foot ulcers.
creator: Ahmad Rizqi Ramadhan
creator: Eva Niamuzisilawati
creator: Tri Nugraha Susilawati
creator: Dhani Redhono Harioputro
rights: Copyright (c) 2026 Ahmad Rizqi Ramadhan, Eva Niamuzisilawati, Tri Nugraha Susilawati, Dhani Redhono Harioputro https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-05-07
publication date: 2026-05-07
volume: 8
number: 1
starting page: 307
ending page: 317
doi: 10.59141/-.v8i1.501

Gingivektomi Pada Enlargement Gingiva Karena Malposisi Gigi Individual
type: item
description: Gingival enlargement is defined as a common clinical sign of gingiva caused directly by plaque that causes gingival inflammation. Gingivectomy is a procedure that can be performed on patients with gingival enlargement. This case report describes the management of gingival enlargement in a case of tooth 42 due to individual tooth malposition. A 20-year-old male patient came to Soelastri Dental and Oral Hospital in Surakarta complaining of swollen gums. The complaint was felt in the upper and lower front gums. The patient was unaware of the swelling, had never received treatment, and did not experience any pain. Gingival treatment for this patient began with phase 1 periodontal therapy followed by gingivectomy. The gingivectomy treatment in this case used a scalpel instrument and the results were effective in reducing the patient's gingival enlargement. The patient was advised to undergo further orthodontic treatment to correct individual tooth malposition.
creator: Salwa Safira
creator: Ariyani Faizah
rights: Copyright (c) 2026 Salwa Safira, Ariyani Faizah https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-01-09
publication date: 2026-01-09
volume: 8
number: 1
starting page: 20
ending page: 27.

Models and Effectiveness of Structured Discharge Planning in the Poststroke Care Transition: A Systematic Literature Review
type: item
description: The transition of care from hospital to home among post-stroke patients is a critical phase associated with risks of functional decline, rehospitalization, and increased caregiver burden. However, limited studies specifically examine the core components of structured discharge planning and its effectiveness across different healthcare contexts. This research aims to synthesize recent evidence on discharge planning models and their effects on post-stroke outcomes, including functional independence, quality of life, rehospitalization, and caregiver-related outcomes. A Systematic Literature Review was conducted following PRISMA 2020 guidelines, with searches in PubMed, Scopus, ProQuest, SAGE, and ScienceDirect for studies published between 2020 and 2025. A total of 22 studies met the inclusion criteria from an initial 641 articles and were analyzed using a narrative-thematic approach. The results indicate that most studies demonstrate high methodological quality, with three main findings: variations in discharge planning models (ESD, TCM, family-based, and telehealth), the central role of nurses in coordination and education, and positive outcomes such as improved activities of daily living, quality of life, self-efficacy, and caregiver resilience, as well as reduced readmission and psychological distress. In conclusion, structured and collaborative discharge planning involving family support is effective in improving transitional care quality, although variations in interventions and outcomes should be considered when interpreting the findings.
creator: Imanuella Imanuella
creator: Azzahra Sida Puspaningrum
creator: Ragil Yunila
creator: Ika Nur Pratiwi
rights: Copyright (c) 2026 Imanuella Imanuella, Azzahra Sida Puspaningrum, Ragil Yunila, Ika Nur Pratiwi https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-05-12
publication date: 2026-05-12
volume: 8
number: 1
starting page: 318
ending page: 336
doi: 10.59141/-.v8i1.510

Postoperative Bleeding Following Involutional Entropion Surgery in an Elderly Patient with a History of Dual Antiplatelet Therapy Use: A Case Report
type: item
description: Elderly patients often undergo dual antiplatelet therapy (DAPT) for cardiovascular conditions, which increases the risk of postoperative bleeding, including after involutional entropion surgery. The management of antiplatelet therapy in the perioperative period remains a clinical challenge that requires careful consideration. This case report aims to discuss the risk of severe postoperative bleeding associated with continuing DAPT during the perioperative period and to emphasize the importance of comprehensive perioperative care in elderly patients undergoing eyelid surgery. A 76-year-old man on DAPT (aspirin and clopidogrel) underwent right involutional entropion surgery. Four days postoperatively, he experienced persistent ocular bleeding requiring hospitalization. Hemoglobin decreased from 12.7 g/dL to 7.5 g/dL, while coagulation parameters remained within normal limits. The patient received a pressure dressing, systemic tranexamic acid, vitamin K, and three units of packed red blood cells. Following cardiology consultation, DAPT was discontinued. The bleeding gradually decreased and completely resolved within six days after DAPT discontinuation. The patient required seven days of hospitalization and blood transfusion due to the significant drop in hemoglobin. No further complications were observed during follow-up. Continuing DAPT during the perioperative period may cause serious postoperative bleeding, even after minor ophthalmic procedures. Careful medication review, multidisciplinary coordination, and patient education are essential to reduce bleeding risk in elderly patients undergoing entropion surgery.
creator: Andyn Robioleny Saparin
creator: Sukoto Sukoto
rights: Copyright (c) 2026 Andyn Robioleny Saparin, Sukoto Sukoto https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-02-21
publication date: 2026-02-21
volume: 8
number: 1
starting page: 69
ending page: 74
doi: 10.59141/-.v8i2.467

The Role of Synbiotics in Modulating the Gut–Brain Axis in Attentiondeficit/Hyperactivity Disorder: A Systematic Review
type: item
description: ADHD is a neurodevelopmental disorder involving gut microbiota dysbiosis and gut–brain pathways, suggesting synbiotics as a potential adjuvant therapy. Literature searches were conducted on electronic primary databases "PubMed", "EuropePMC", and "ScienceDirect" with a range published between 2020–2025. Studies were selected based on inclusion criteria and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The methodological quality of the included studies was evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Tools for randomized clinical trials. Of the 146 articles identified, five randomized clinical trial studies met the inclusion criteria. The available evidence suggests that synbiotic interventions have varied clinical effects in ADHD patients. More obvious benefits are mainly seen in the symptomatic aspects of inattention, with secondary impacts on impulse control and adaptive function of daily behavior, as well as inflammatory biomarkers and gut microbiota. No serious side effects were reported in any of the included studies. This systematic review suggests that synbiotics have the potential to modulate the two-way gut-brain communication pathway and provide domain-specific clinical benefits in subgroups of ADHD patients with specific clinical or biological characteristics. These findings support the role of synbiotics as adjuvant therapy, but are not enough to recommend it as a single therapy for the entire ADHD patient population in general.
creator: Elfrida Noor Auliya
creator: Margarita M. Maramis
rights: Copyright (c) 2026 Elfrida Noor Auliya, Margarita M. Maramis https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-06-17
publication date: 2026-06-17
volume: 8
number: 1
starting page: 450
ending page: 464
doi: 10.59141/-.v8i1.518

A Comprehensive Systematic Review of the Association Between Vitamin D Deficiency and Alopecia Areata
type: item
description: Alopecia areata (AA) is a non-scarring hair loss disorder commonly considered an autoimmune condition in which the immune system attacks the hair follicle during the anagen phase. Vitamin D is a fat-soluble hormone primarily known for regulating calcium homeostasis via the vitamin D receptor (VDR), which is expressed in various cells including immune cells and hair follicles. This systematic review aims to examine the association between vitamin D deficiency and alopecia areata. The study followed the PRISMA 2020 guidelines. A literature search was conducted using databases including PubMed, SagePub, and ScienceDirect for articles published between 2014 and 2024. Review articles, duplicates, and incomplete studies were excluded. Results: From 1,751 initially identified articles, only eight studies met the inclusion criteria after a three-step screening process. All eight full-text articles were analyzed in depth. Vitamin D levels demonstrate an inverse relationship with the severity, extent, and pattern of alopecia areata. Thus, vitamin D deficiency may serve as a contributing factor in the pathogenesis of AA or may exacerbate the existing condition.
creator: Salsabilla Gina Rania
creator: Nanda Khirana Bangsawan Puteri
rights: Copyright (c) 2026 Salsabilla Gina Rania, Nanda Khirana Bangsawan Puteri https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-05-16
publication date: 2026-05-16
volume: 8
number: 1
starting page: 376
ending page: 386
doi: 10.59141/-.v8i1.477

Overview of the Level of Knowledge and Behavior of Social Rehabilitation and Child Care Center (BRSPA) Officers in Bimomartani Regarding COVID-19
type: item
description: COVID-19 is an infectious disease caused by the SARS-CoV-2 virus and was declared a global pandemic by the WHO in March 2020. The high number of cases in Indonesia, including in Sleman Regency, requires increased vigilance in various social institutions, including the Bimomartani Social Rehabilitation and Child Care Center (BRSPA), which has a child population that is highly vulnerable to infection. The transmission cases within the BRSPA environment demonstrate the importance of staff knowledge and behavior in preventing COVID-19. This study aims to describe the level of knowledge and behavior of Bimomartani BRSPA staff regarding COVID-19. This study used a quantitative descriptive design with a cross-sectional approach. The sample was drawn using a total sampling technique with 33 respondents. Data were collected through a validated questionnaire distributed online using Google Forms. Data analysis was conducted descriptively to illustrate the distribution of knowledge and behavior levels based on respondent characteristics. The study showed that 90.1% of respondents had good knowledge and behavior regarding COVID-19, while 9.9% had inadequate knowledge and behavior. Levels of knowledge and behavior were not evenly distributed across gender, age group, and education level. Furthermore, it was found that knowledge levels did not always align with preventive behaviors among some respondents. In general, Bimomartani BRSPA officers have good knowledge and behavior regarding COVID-19, but efforts are still needed to improve and equitably distribute health education to strengthen the consistent implementation of preventive behaviors.
creator: Prastika Dica Izwara
creator: Wulandari Berliani Putri
rights: Copyright (c) 2026 Prastika Dica Izwara, Wulandari Berliani Putri https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-13
publication date: 2026-03-13
volume: 8
number: 1
starting page: 167
ending page: 177
doi: 10.59141/-.v8i1.485

A Lifestyle with Moderate-to-Vigorous Physical Activity Lowers Resting Heart Rate in Adolescents
type: item
description: Physical activity plays an important role in maintaining cardiovascular health and preventing early cardiometabolic risk. However, global evidence indicates that a large proportion of adolescents do not meet the recommended levels of physical activity, which may negatively influence cardiovascular indicators such as resting heart rate (RHR). Elevated RHR has been widely recognized as an early marker of cardiovascular risk and autonomic imbalance. This study aimed to analyze the association between physical activity levels and resting heart rate among adolescents aged 20–24 years. This research employed an analytic observational design with a cross-sectional approach. A total of 100 participants were recruited using convenience sampling from the Faculty of Medicine, Duta Wacana Christian University, Yogyakarta. Physical activity levels were assessed using the International Physical Activity Questionnaire Long Form (IPAQ-L), while resting heart rate was measured through radial pulse palpation after a five-minute seated rest. Statistical analysis was conducted using SPSS software with Chi-square testing. The results showed that 47% of participants engaged in moderate physical activity, 24% in vigorous activity, and 29% in low activity. Most participants (62%) had a resting heart rate above 80 bpm. A significant inverse association was found between physical activity level and resting heart rate (p = 0.019), indicating that adolescents with higher levels of physical activity tended to have lower resting heart rates. In conclusion, moderate-to-vigorous physical activity is associated with healthier resting heart rate values, suggesting improved cardiovascular function in adolescents.
creator: Stanley Lovell Hanson
creator: Christiane Marlene Sooai
rights: Copyright (c) 2026 Stanley Lovell Hanson, Christiane Marlene Sooai https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-28
publication date: 2026-03-28
volume: 8
number: 1
starting page: 235
ending page: 242
doi: 10.59141/-.v8i1.493

Effectiveness of Balloon Sinuplasty Compared to Functional Endoscopic Sinus Surgery in The Management of Chronic Rhinosinusitis
type: item
description: This study addresses the growing clinical interest in minimally invasive surgical approaches for managing chronic rhinosinusitis (CRS), particularly the use of Balloon Sinuplasty (BSP) as an alternative to Functional Endoscopic Sinus Surgery (FESS). While FESS remains the gold standard for severe CRS, BSP has gained attention due to its reduced invasiveness and faster recovery. The purpose of this study is to compare the effectiveness of BSP and FESS in improving clinical outcomes among CRS patients. This research employed a descriptive-analytical literature review approach by analyzing scientific articles from databases such as PubMed, Scopus, and Google Scholar. Selected studies include randomized controlled trials, cohort studies, and meta-analyses that meet established inclusion criteria. Key variables assessed include symptom improvement, quality of life, complication rates, sinus patency, and recovery time. The findings indicate that both BSP and FESS significantly improve symptoms and quality of life, with comparable outcomes in selected patient populations. BSP demonstrates advantages in terms of lower complication rates, reduced intraoperative bleeding, and shorter recovery time, while FESS remains more effective in severe or complex cases involving nasal polyps. In conclusion, both procedures are effective treatment options for CRS, and the choice of intervention should be individualized based on disease severity, anatomical factors, and patient characteristics to achieve optimal clinical outcomes
creator: Maria Cecilia Gritce Widjaja
creator: Ahmad Fauzi
rights: Copyright (c) 2026 Maria Cecilia Gritce Widjaja, Ahmad Fauzi https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-04-20
publication date: 2026-04-20
volume: 8
number: 1
starting page: 282
ending page: 293
doi: 10.59141/-.v8i1.499

Pendekatan Kedokteran Keluarga Melalui Kunjungan Rumah Pada Pasien Diabetes Melitus Tipe 2 Dan Hipertensi Di Kota Surabaya: Sebuah Laporan Kasus
type: item
description: Pendekatan kedokteran keluarga berperan penting dalam pengelolaan penyakit kronis, terutama pada lansia dengan komorbiditas dan keterbatasan sosial-ekonomi. Laporan kasus ini bertujuan menggambarkan penerapan kunjungan rumah pada seorang pasien lansia dengan diabetes melitus tipe 2 dan hipertensi di Kota Surabaya, dengan penekanan pada fungsi keluarga, sumber daya lingkungan, dan determinan kesehatan menurut kerangka HL Blum. Studi ini merupakan laporan kasus deskriptif kualitatif. Data diperoleh melalui satu rangkaian kunjungan rumah meliputi anamnesis komprehensif, pemeriksaan fisik dan penunjang sederhana, observasi lingkungan rumah, penyusunan genogram, penilaian fungsi keluarga dengan Family APGAR, dan asesmen sumber daya keluarga menggunakan SCREEM. Pasien berusia 67 tahun dengan riwayat diabetes melitus tipe 2 selama ±10 tahun dan hipertensi ±8 tahun, datang dengan keluhan pandangan kabur, obesitas sentral, dislipidemia, dan hiperurisemia; tekanan darah 160/100 mmHg dan gula darah sewaktu 221 mg/dL menunjukkan penyakit yang belum terkontrol. Family APGAR menunjukkan fungsi keluarga kategori sedang, dengan dukungan utama berpusat pada istri dan keterlibatan anak yang terbatas. Asesmen SCREEM mengidentifikasi hambatan pada aspek sosial, budaya, ekonomi, edukasi, dan medis, sementara aspek religius bersifat protektif. Pemetaan dengan kerangka HL Blum menegaskan bahwa interaksi faktor keturunan, perilaku berisiko, lingkungan yang kurang mendukung, dan keterbatasan pelayanan kesehatan berkontribusi terhadap buruknya pengendalian penyakit, sekaligus menegaskan nilai strategis kunjungan rumah dalam merancang tatalaksana bio-psiko-sosial-spiritual yang komprehensif dan berorientasi keluarga.
creator: Johanes Aprilius Falerio Kristijanto
creator: Wike Herawaty
creator: Ayu Cahyani Noviana
creator: Farida Anggraini Soetedjo
creator: Nur Khamidah
rights: Copyright (c) 2026 Johanes Aprilius Falerio Kristijanto, Wike Herawaty, Ayu Cahyani Noviana, Farida Anggraini Soetedjo, Nur Khamidah https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-01-09
publication date: 2026-01-09
volume: 8
number: 1
starting page: 1
ending page: 19

Management of Post-Mastoidectomy Retroauricular Wound Dehiscence Using Advancement Flap: Case Report
type: item
description: Mastoidectomy with tympanoplasty commonly requires a postauricular incision and may be complicated by retroauricular wound dehiscence, particularly in the presence of infection, tissue tension, or impaired local perfusion. Persistent wound dehiscence can delay healing, compromise cosmetic outcomes, and necessitate secondary reconstructive procedures. Local advancement flaps and skin grafting are among the reconstructive options described. The purpose to report the clinical outcome of post-mastoidectomy retroauricular wound dehiscence managed using an advancement flap and review supporting evidence for this technique. Case report: A 52-year-old man with chronic suppurative otitis media with cholesteatoma underwent canal wall up mastoidectomy with tympanoplasty. During postoperative follow-up, retroauricular wound dehiscence complicated by local infection was identified. Surgical reconstruction was performed using a retroauricular advancement flap under general anesthesia. Postoperative follow-up demonstrated satisfactory wound closure, progressive epithelialization, and acceptable cosmetic outcomes, with no recurrence or major complications. Clinical question: Does advancement flap reconstruction offer better outcomes compared to skin grafting in post-mastoidectomy retroauricular wound dehiscence? Method: A literature search was conducted in PubMed, ScienceDirect, and Google Scholar to identify relevant studies on the management of post-mastoidectomy retroauricular wound dehiscence using advancement flaps or skin grafts. Seven relevant articles were identified. Case reports and small case series demonstrated high primary wound closure rates and low recurrence following advancement flap reconstruction. Skin grafting facilitated epithelialization in selected cases but showed variable outcomes in compromised wound beds. Advancement flap reconstruction is an effective and reliable option for managing retroauricular wound dehiscence following mastoidectomy, particularly i…
creator: Dewi Pratiwi
creator: Desnita Monica
rights: Copyright (c) 2026 Dewi Pratiwi, Desnita Monica https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-05-12
publication date: 2026-05-12
volume: 8
number: 1
starting page: 367
ending page: 375
doi: 10.59141/-.v8i1.505

Modified Coronally Advanced Flap Technique for Managing Orthodontic Related Gingival Recession
type: item
description: Background: Gingival recession is one of the most common mucogingival deformities requiring surgical correction. Various mucogingival therapies are available as treatment options for gingival recession, such as connective tissue graft, coronally positioned flap, and acellular dermal matrix application. The acellular dermal matrix (ADM) contains undamaged collagen and elastin matrices and can be used as a substitute for a connective tissue graft (CTG) during the root coverage procedure. This case report studies the effects of ADM graft (SureDerm®) combined with coronally advanced flap (CAF) on root coverage and aesthetics for the treatment of multiple gingival recessions associated with orthodontic treatment in patients with a thin gingival phenotype. A 25-year-old male patient presented to the Periodontics Specialist Clinic at the Dental Hospital, Universitas Airlangga, with the chief complaint of dental hypersensitivity and aesthetic concerns in the maxillary central incisors. The patient had undergone orthodontic treatment for two years and had worn a mandibular lingual retainer for two years before the mucogingival therapy. A modified envelope papilla preservation technique with the additional use of acellular dermal matrix (SureDerm®) was performed to improve gingival thickness and reduce recession length. The three-month follow-up showed an increase in gingival thickness and a decrease in recession length. The success of this treatment depends on the surgical technique and procedure used, and it is measured by the absence of further complaints and the correction of gingival recession. The coronally advanced flap technique with the additional use of acellular dermal matrix (SureDerm®) is effective for managing orthodontic-related gingival recession.
creator: Fabia Yustiaputri
creator: Eka F Augustina
creator: I Gusti A Aditya Putra
rights: Copyright (c) 2026 Fabia Yustiaputri, Eka F Augustina, I Gusti A Aditya Putra https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-03
publication date: 2026-03-03
volume: 8
number: 1
starting page: 125
ending page: 131
doi: 10.59141/-.v8i2.462

Predictors of Self-Efficacy in Patients with Chronic Obstructive Pulmonary Disease
type: item
description: Chronic obstructive pulmonary disease (COPD) is a growing global health concern with increasing morbidity and mortality. Self-efficacy plays a key role in COPD self-management, influencing patients’ ability to control symptoms, perform daily activities, manage emotions, and access health information. Identifying factors that affect self-efficacy is essential to improve patient outcomes and quality of life. This quantitative cross-sectional study involved 100 outpatient COPD patients at Respira Hospital Yogyakarta. Data were collected using the validated Indonesian version of the Chronic Self-Management Scale (CSMS) and analyzed through univariate and multiple linear regression methods. The mean self-efficacy score was 35.83 (SD = 7.609). Regression analysis showed that symptom management, activity management, emotional management, and information management collectively had a significant effect on self-efficacy (p = 0.001; R = 0.582; R² = 0.339). Partially, emotional management (p < 0.001) and information management (p = 0.026) were significant predictors, while symptom management (p = 0.092) and activity management (p = 0.266) were not. In conclusion, emotional and information management are key predictors of self-efficacy in COPD patients, with emotional management as the most dominant factor. Interventions should prioritize emotional regulation and improving health literacy to enhance self-efficacy and overall quality of life.
creator: Scholastica Fina Aryu Puspasari
rights: Copyright (c) 2026 Scholastica Fina Aryu Puspasari https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-06-11
publication date: 2026-06-11
volume: 8
number: 1
starting page: 428
ending page: 437
doi: 10.59141/-.v8i1.514

The Effect of Isometric Forearm Contraction Exercises Added to Elderly Gymnastics on Blood Glucose Levels and Blood Pressure Among Older Adults in Kebumen
type: item
description: The global elderly population continues to rise, with Indonesia ranking fourth worldwide. The increasing number of older adults is accompanied by a rising prevalence of non-communicable diseases such as hypertension and diabetes mellitus. In the Mutiara Sari Kebumen Elderly Community (34 members), low physical activity levels have been observed, increasing vulnerability to these health problems. Therefore, appropriate interventions are needed to help reduce blood sugar levels and blood pressure through the activation of regular physical activity. This study aimed to determine the effects of elderly gymnastics with and without isometric handgrip exercises on blood sugar levels and blood pressure, as well as to compare the effectiveness of the two interventions among elderly members of the Mutiara Sari Kebumen community. This research employed a quasi-experimental pre-test and post-test control group design. The study subjects were 34 elderly individuals aged 60–74 years, selected using a total sampling technique. Participants followed an exercise program five times per week for four weeks. Instruments used included the Easy Touch GCU device and a sphygmomanometer. Data were analyzed using descriptive statistics, normality and homogeneity tests, and hypothesis testing. Paired Sample T-Test results showed significant effects in both groups (p = 0.000; p < 0.05). However, Independent Sample T-Test results indicated no significant difference between the two interventions in reducing blood sugar and blood pressure. Both elderly gymnastics alone and in combination with isometric handgrip exercises effectively reduced blood sugar levels and blood pressure, with no significant difference between the two interventions
creator: Asifa Maura Salsabila
creator: Moh. Ali Imran
creator: Tri Laksono
rights: Copyright (c) 2026 Asifa Maura Salsabila, Moh. Ali Imran https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-02-21
publication date: 2026-02-21
volume: 8
number: 1
starting page: 75
ending page: 91
doi: 10.59141/-.v8i2.475

Comparing the Oncological Risk of Hormonal and Non-Hormonal Contraceptives in Cervical Cancer: A Literature Review
type: item
description: Cervical cancer is a malignancy with high morbidity and mortality rates among women worldwide, including Indonesia. While high-risk HPV (hr-HPV) infection is the primary cause, contraceptive use is strongly suspected to act as a significant cofactor in cervical carcinogenesis. This research aims to analyze the comparison of cervical cancer risk between hormonal and non-hormonal contraceptive use through a comprehensive literature review. The study design was a literature review with a systematic search strategy on PubMed and Google Scholar databases. Ten original research articles (5 national and 5 international journals) published between 2016 and 2026 were selected based on inclusion and exclusion criteria. The analysis results showed that 60% of the studies reported a significant association between long-term hormonal contraceptive use ≥ 5 years and an increased risk of cervical cancer, with Odds Ratio (OR) values ranging from 2.4 to 7.0. In contrast, non-hormonal contraceptive use, specifically the Intrauterine Device (IUD), consistently showed a lower risk profile or provided a protective effect against pre-cancerous lesions. However, some studies showed variations influenced by confounding factors such as age at first marriage and parity. Long-term hormonal contraceptive use is associated with an increased risk of cervical cancer, while non-hormonal contraceptives (IUD) have a better oncological safety profile. Comprehensive counseling and routine screening (VIA/Pap Smear) are required for contraceptive acceptors, especially long-term hormonal method users.
creator: Haifa Hasna Putri
creator: Fiona Paramitha
rights: Copyright (c) 2026 Haifa Hasna Putri, Fiona Paramitha https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-05-12
publication date: 2026-05-12
volume: 8
number: 1
starting page: 358
ending page: 366
doi: 10.59141/-.v8i1.523

The Relationship Between Job Type and the Incidence of Osteoarthritis at the Unaaha Community Health Center
type: item
description: Osteoarthritis (OA) is a degenerative joint disease characterized by damage to joint cartilage. Osteoarthritis can be influenced by several factors, namely systemic factors (age, sex, and heredity), intrinsic factors (anatomical abnormalities and injuries), and extrinsic factors (obesity, joint overuse, and occupation). This study aims to determine the relationship between job type and the incidence of osteoarthritis at the Unaaha Community Health Center. This study uses an analytical observational method with a cross-sectional approach. This research was conducted in the Konawe Regency area, specifically at the Unaaha Community Health Center. The sample in the study consisted of 68 respondents obtained using the purposive sampling technique. Data were obtained through medical records and then analyzed using the chi-square test and were considered statistically significant if p < 0.05. The results of the bivariate analysis examining the relationship between job type and the incidence of osteoarthritis at the Unaaha Community Health Center yielded a value of p = 0.034, which is less than α (0.05); thus, it can be stated that there is a statistically significant relationship between job type and the incidence of osteoarthritis. The conclusion of this study is that there is a significant relationship between job type and the incidence of osteoarthritis at the Unaaha Community Health Center.
creator: Miranda Septiani
creator: Amirudin Eso
creator: La Rangki
rights: Copyright (c) 2026 Miranda Septiani Septiani https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-10
publication date: 2026-03-10
volume: 8
number: 1
starting page: 132
ending page: 141
doi: 10.59141/-.v8i1.482

Quality and Safety Profile of Chili Sauce in Cirebon City
type: item
description: The quality and safety standards of chili sauce are determined in SNI 01-2976-2006. It states that if chili sauce is not handled and processed properly, it can be contaminated with hazardous substances that cause disease or poisoning, such as Rhodamine B. Long-term consumption of Rhodamine B may lead to liver dysfunction or malignancy. To observe the quality and safety of chili sauce based on its characteristics and to identify the use of Rhodamine B dye in chili sauce sold with snacks around Bima Stadium. This study was conducted descriptively using a qualitative laboratory approach at the Research Laboratory of Swadaya Gunung Jati University. Sampling was carried out using total sampling from food vendors around Bima Stadium, Cirebon City, who met the inclusion criteria. Samples were examined for chili sauce characteristics in terms of aroma, appearance, and color and tested for Rhodamine B content using the Rhodamine B Rapid Test Kit (Labtest Reagent®). Data were obtained from 18 samples, analyzed descriptively, and presented in tables accompanied by narrative explanations. Of the 18 samples, 2 samples (11.1%) of chili sauce tested positive for Rhodamine B, while 16 samples (88.9%) were negative. Abnormal aromatic characteristics were found in 3 samples (16.7%), whereas 15 samples (83.3%) were normal. Based on appearance, 4 samples (22.2%) were abnormal and 14 samples (77.8%) were normal. In terms of color, 2 samples (11.1%) were abnormal and 16 samples (88.9%) were normal. Rhodamine B and abnormal physical characteristics were found in some chili sauce samples.
creator: Salwa Oksiputri Aulia
rights: Copyright (c) 2026 Salwa Oksiputri Aulia https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-14
publication date: 2026-03-14
volume: 8
number: 1
starting page: 188
ending page: 201
doi: 10.59141/-.v8i1.490

The Role of Vitamin D in Endometrial Receptivity for Successful Implantation
type: item
description: Successful embryo implantation depends on endometrial receptivity during the implantation window, which involves gene regulation, decidualization, and local immune modulation. Vitamin D has received attention due to the expression of the vitamin D receptor (VDR) in the endometrium and its role in regulating receptor gene transcription. To review the scientific evidence regarding the association of vitamin D levels with endometrial receptivity and implantation outcomes in assisted reproductive technology (ART). A literature review was conducted through a systematic search of PubMed, Google Scholar, and ScienceDirect (2020–2026). Observational human studies assessing vitamin D levels on endometrial parameters or pregnancy outcomes were included; eight studies met the criteria. Vitamin D plays a role in the regulation of HOXA10, HAND2, decidualization, and the tolerogenic immune balance. However, clinical outcomes are heterogeneous; some studies show benefits primarily in deficiency states, while others find no significant associations with implantation rate or live birth rate. Vitamin D has the potential to be a permissive factor in endometrial receptivity, but it is not a primary determinant of implantation success.
creator: Nur Fadilah
rights: Copyright (c) 2026 Nur Fadilah https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-28
publication date: 2026-03-28
volume: 8
number: 1
starting page: 243
ending page: 253
doi: 10.59141/-.v8i1.497

https://www.jusindo.publikasiindonesia.id.solusipublish.com/index.php/jsi/article/view/503
type: item
title: Acute Low-Tone Sensorineural Hearing Loss Presenting With Non-Rotatory Vestibular Prodrome in a High-Risk Patient: A Comprehensive Case Report on Aggressive Systemic Corticosteroid Management and Prognostic Evaluation
description: Acute Low-Tone Hearing Loss (ALHL) is often recognized as the clinical manifestation of cochlear-restricted endolymphatic hydrops (EH), making it highly prone to recurrence and subsequent conversion into definitive Menière's Disease (MD). Given this risk, necessitate immediate and aggressive therapeutic intervention to stabilize inner ear function. This research aims to study the therapy and observation in patients with ALHL. Case Report A 27-year-old female presented with acute unilateral tinnitus, aural fullness and new-onset subtle, non-rotatory dizziness, unsteadiness and an episode of nausea and vomiting. Pure tone audiometry, showed a low tone sensorineural hearing loss. What do we have to consider in treatment of patient with ALHL to avoid worsening progression and achieve complete recovery? Literature research was carried out through PubMed and Google Scholar with keywords "Acute Low Tone Hearing Loss" AND "Sudden Sensorineural Hearing Loss" AND "Therapy". Based on the search, we found recommendations in managing patient of ALHL, such as high-dose corticosteroids, pure-tone audiometric evaluation, anti-hydrops agents, and other supportive management. There are several considerations in ALHL therapy in patients that should be carried out carefully and with comprehensive, prolonged audio vestibular surveillance.
creator: Marsella Lulu Aulia
creator: Gustav Syukrinto
rights: Copyright (c) 2026 Marsella Lulu Aulia, Gustav Syukrinto https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-04-14
publication date: 2026-04-14
volume: 8
number: 1
starting page: 267
ending page: 274
doi: 10.59141/-.v8i1.503

Asuhan Akupunktur pada Penderita Kecemasan di Rumah Sehat Alam Borneo Sangatta
type: item
description: Gangguan kecemasan merupakan masalah kesehatan mental yang berdampak kompleks pada aspek fisik dan psikologis. Penelitian ini bertujuan untuk mengetahui penerapan asuhan akupunktur pada penderita kecemasan di Rumah Sehat Alam Borneo Sangatta, propinsi Kalimantan Timur. Metode penelitian menggunakan pendekatan kualitatif dengan desain studi kasus pada seorang partisipan laki-laki berusia 51 tahun yang mengalami kecemasan berat dan insomnia. Berdasarkan pemeriksaan Traditional Chinese Medicine (TCM), partisipan didiagnosis mengalami sindrom Stagnasi Qi Hati disertai Defisiensi Qi Limpa. Intervensi dilakukan sebanyak enam sesi selama empat minggu pada Desember 2025 menggunakan titik utama Taichong (LR3), Neiguan (PC6), Shenmen (HT7), Zusanli (ST36), Sanyinjiao (SP6), dan Baihui (GV20). Hasil penelitian menunjukkan perbaikan signifikan baik secara subjektif maupun objektif. Keluhan cemas menurun, kualitas tidur membaik dari sulit tidur menjadi 5–6 jam per malam, serta keluhan penyerta seperti gangguan pencernaan dan kelelahan teratasi. Secara objektif, kondisi Shen menjadi segar, selaput lidah menipis, dan nadi menjadi stabil. Disimpulkan bahwa terapi akupunktur efektif dalam menangani gangguan kecemasan dengan prinsip menenangkan Shen, melancarkan aliran Qi, dan menguatkan Limpa.
creator: Deddy Eko Wahyudi
creator: Mayang Wulandari
creator: Ikhwan Abdullah
creator: Leny Candra
rights: Copyright (c) 2026 Deddy Eko Wahyudi, Mayang Wulandari, Ikhwan Abdullah, Leny Candra https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-02-27
publication date: 2026-02-27
volume: 8
number: 1
starting page: 99
ending page: 107
doi: 10.59141/-.v8i2.446

Iron Deficiency n Pregnancy and its Impact on Mother and Fetus: A Systematic Review in Experimental Animal Models
type: item
description: Iron deficiency is a common nutritional problem during pregnancy and is associated with maternal anemia and adverse pregnancy outcomes. Although clinical evidence in humans is widely available, mechanistic understanding of the impact of iron deficiency on the materno-fetal unit is still limited and requires support from experimental animal studies. This systematic review aims to comprehensively review the evidence from animal studies on the impact of iron deficiency during pregnancy on maternal health, placental function, and fetal development. Literature searches were conducted on PubMed, Scopus, and Web of Science databases for articles published between 2016–2025, following PRISMA guidelines. Studies that used models of pregnant animals with iron deficiency induction and reported maternal or fetal outcomes were included. Bias risk assessment was carried out using the SYRCLE tool. Seven studies met the inclusion criteria. Consistently, maternal iron deficiency causes anemia in the mother, placental dysfunction, increased oxidative stress, and inhibition of fetal growth and development. Evidence from animal models confirms the important role of iron in maintaining pregnancy health and provides a translationally relevant mechanistic basis for conditions in humans.
creator: Dinda Fachri
creator: Ahmad Aulia Jusuf
rights: Copyright (c) 2026 Dinda Fachri, Ahmad Aulia Jusuf https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-06-10
publication date: 2026-06-10
volume: 8
number: 1
starting page: 414
ending page: 427
doi: 10.59141/-.v8i1.511

Design of a Web-Based Daily Inpatient Census Information System Interface at the Kanjuruhan Regional General Hospital
type: item
description: The Daily Census of Inpatients (Sensus Harian Rawat Inap [SHRI]) at Kanjuruhan Hospital is still carried out manually using spreadsheets, which has the potential to cause reporting delays, data input errors, and low accuracy of information needed for hospital management decision-making. This study aims to design a web-based SHRI information system interface that suits the needs of users and improves the efficiency, accuracy, and quality of recording and reporting of inpatient data. The research uses a descriptive method with a qualitative and quantitative approach. Data were collected through interviews, observations, and questionnaires distributed to inpatient and medical record officers. The evaluation of the interface design was carried out using a usability questionnaire with a Likert scale. The results of the study show that the interface design developed is able to simplify the process of recording and reporting SHRI, improve data accuracy, and speed up information access. The usability evaluation yielded an average score of 84.4%, categorized as satisfied, indicating that the system is well received by users. The web-based SHRI information system interface design is considered effective, easy to use, and in accordance with user needs, thus having the potential to improve the quality of inpatient data management and support hospital management decision-making more optimally.
creator: Rahmadyo Yudhi Prabowo
creator: Riyan Pramudiya
rights: Copyright (c) 2026 Rahmadyo Yudhi Prabowo, Riyan Pramudiya https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-18
publication date: 2026-03-18
volume: 8
number: 1
starting page: 202
ending page: 222
doi: 10.59141/-.v8i1.468

https://www.jusindo.publikasiindonesia.id.solusipublish.com/index.php/jsi/article/view/519
type: item
title: The Relationship Between Knowledge, Attitudes, and Supporting Factors Among Women of Reproductive Age Regarding Cervical Cancer and Their Interest in Undergoing an Iva Test in the Service Area of the Talun Community Health Center, Cirebon Regency
description: Cervical cancer is the 4th leading cause of death in women worldwide and the 2nd in Indonesia. The prevalence of cervical cancer in 2022 in Asia was 1,186,812 cases, Indonesia 36,964 cases, West Java 565 cases. Early detection of cervical cancer can be done using the IVA test method. There are several factors for WUS in conducting the IVA test, including knowledge, attitude, supporting factors and interest. This research aimed to To determine the correlation between knowledge, attitudes and supporting factors of women in reproductive age regarding cervical cancer with interest in conducting IVA tests in the working area of Talun Health Center, Cirebon Regency. This research used an analytic observational design to 100 women of reproductive age in the working area of Talun Health Center using a cross-sectional approach with a questionnaire. Data analysis used the Spearman correlation test (bivariate) and logistic regression test (multivariate). The result bivariate analysis showed a significant correlation between women of reproductive age's knowledge (P<0.05), attitude (P<0.05), and supporting factors based on affordability (P<0.05), information sources (P<0.05), and accessibility of health facilities (P<0.05) with interest to commit IVA test. Multivariate analysis showed attitude sources were the most influential factor on the interest in conducting the IVA test (P<0.05). Attitude is the most significant factor correlated with the willingness of women of reproductive age in the Talun Community Health Center working area to undergo IVA tests. Therefore, healthcare providers should enhance educational efforts and understanding regarding cervical cancer and the IVA test.
creator: Cecep Rohendi
creator: Thysa Thysmelia Affandi
creator: Thysa Shofa Nur Fauzah
rights: Copyright (c) 2026 Cecep Rohendi, Thysa Thysmelia Affandi, Thysa Shofa Nur Fauzah https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-05-12
publication date: 2026-05-12
volume: 8
number: 1
starting page: 337
ending page: 350
doi: 10.59141/-.v8i1.519

Rare Case Report: Guillain–Barré Syndrome As A Neurological Complication In Patients With Dengue Fever
type: item
description: Dengue virus infection has many complications, one of the rare neurological complications is Guillain-Barre syndrome (GBS). Dengue virus is classified into four serotypes, namely DENV-1, DEN-2, DEN-3 and DEN-4, while the most frequent causes of neurological complications are DEN-2 and DEN-3. This case report aims to a rare case of Guillain-Barré syndrome as a neurological complication of dengue fever and highlight the importance of early diagnosis and management. Case Reports: A 46-year-old man has had two main complaints of weak limbs, tingling and numbness since the last 5 days, followed by complaints of both weak arms, tingling and numbness since the last 4 days, accompanied by heartburn pain and double vision. The patient had a previous hospitalization history 10 days ago with a diagnosis of dengue fever with a positive NS 1 result. The physical examination found that the lateralized muscle strength of the sinistra and physiological reflexes were reduced in both legs and both arms, pain sensations and palpable sensations were reduced. The results of the examination are in accordance with the results of the ENMG examination, namely the AMSAN type GBS. Currently, patients are diagnosed with GBS as a sequel to dengue fever infection. The pathogenesis of GBS caused by the dengue virus is mediated by the immune system against the DEN serotype that affects peripheral nerves. Based on previous case reports, GBS cases are one of the neurological complications of dengue fever. GBS is one of the neurological complications in patients with dengue fever.
creator: R Zhafira Arrum Prabapatitis
creator: Muhammad Adam Prabasunu
rights: Copyright (c) 2026 R Zhafira Arrum Prabapatitis, Muhammad Adam Prabasunu https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-02-28
publication date: 2026-02-28
volume: 8
number: 1
starting page: 117
ending page: 124
doi: 10.59141/-.v8i2.480

Targeting TLR4 Signaling Pathway in Degenerative Diseases: Molecular Docking Study of Bioactive Compounds from Ramie (Boehmeria Nivea) as Anti-Inflammatory and Antioxidant Agents
type: item
description: Toll-like receptor 4 (TLR4) acts as an upstream regulator that links chronic inflammation and oxidative stress through activation of the NF-κB pathway as well as the production of reactive oxygen species (ROS), thereby contributing to the progression of various degenerative diseases. Ramie (Boehmeria nivea) kombucha is known to contain polyphenol compounds and bioactive organic acids that have the potential to act as nutraceutical agents, but the molecular mechanisms of their interaction with the TLR4 pathway are still not fully analyzed. This study used the network pharmacology and molecular docking approaches to evaluate the potential of bioactive compounds of hemp leaf kombucha in targeting TLR4 in silico. Analysis of protein networks shows that Toll-like Receptor 4 (TLR4) has a central role as the main binding protein in inflammatory pathways and oxidative stress based on the high degree of connectivity in protein–protein interaction networks. Molecular docking simulations show that all ligands are able to bind to the active site. The flavonoid compound catechin showed the most stable binding affinity with a value of −7.8 kcal/mol, followed by quercetin of −7.4 kcal/mol, while organic acid compounds such as D-glucuronic acid, gluconic acid, and citric acid were in the range of −4.8 to −5.9 kcal/mol. The stability of the ligand–receptor complex is confirmed by the Root Mean Square Deviation (RMSD) value ≤ 2 Å. The ligand–receptor interaction is dominated by the formation of hydrogen bonds and hydrophobic interactions on amino acid residues at the TLR4 binding site, which contributes to the stability of the complex.
creator: Bruneitabba Billal Irawan
rights: Copyright (c) 2026 Bruneitabba Billal Irawan https://creativecommons.org/licenses/by-sa/4.0
license: https://creativecommons.org/licenses/by-sa/4.0
date: 2026-03-10
publication date: 2026-03-10
volume: 8
number: 1
starting page: 142
ending page: 149
doi: 10.59141/-.v8i1.488